Evidence supporting the use of: Leucoanthocyanins
For the body system: Veins

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Leucoanthocyanins, also known as proanthocyanidins, are a class of polyphenolic compounds widely found in plants, especially in grape seeds, pine bark, and other fruits. Their use in supporting the venous system primarily stems from their recognized antioxidant and vasoprotective properties. Scientific studies have shown that proanthocyanidins can strengthen capillary walls, reduce capillary permeability, and improve microcirculation. These effects are particularly relevant in conditions such as chronic venous insufficiency (CVI), varicose veins, and hemorrhoids.

Clinical trials, especially with standardized extracts like French maritime pine bark extract (Pycnogenol) and grape seed extract, have demonstrated improvements in symptoms such as leg swelling, pain, and a sensation of heaviness in patients with CVI. The proposed mechanisms include inhibition of free radical formation, protection of vascular endothelial cells, and modulation of inflammatory mediators involved in vascular permeability.

While the data is not as robust or extensive as for pharmaceutical interventions, meta-analyses and systematic reviews conclude there is moderate evidence for the benefit of proanthocyanidins in venous disorders. The majority of studies are of short duration, and more high-quality, long-term research is needed. However, the existing scientific literature does provide a reasonable basis for their use in supporting venous health.

More about Leucoanthocyanins
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Other body systems supported by Leucoanthocyanins

Arteries
Blood
Capillaries
Circulatory System
Eyes
Gums
Heart
Skin
Veins

Products containing Leucoanthocyanins

We currently have no products on Vitabase that contain this ingredient.