Evidence supporting the use of: Proanthocyanidin (unspecified)
For the body system: Veins

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, particularly those extracted from sources like grape seed and pine bark, have been the subject of clinical and preclinical research for their effects on venous health. These polyphenolic compounds are known for their antioxidant properties, which may help protect blood vessels from oxidative stress and support vascular integrity. Several randomized controlled trials and meta-analyses have explored the use of proanthocyanidin-rich extracts (notably pycnogenol or grape seed extract) in individuals with chronic venous insufficiency (CVI), varicose veins, and related symptoms like leg swelling, pain, and heaviness.

Studies suggest that proanthocyanidins may improve capillary strength and decrease capillary permeability, thereby reducing edema and discomfort associated with venous disorders. The European Medicines Agency (EMA) and other regulatory bodies recognize the traditional and emerging scientific use of proanthocyanidin-containing extracts for supporting venous circulation, although most high-quality evidence is limited to specific standardized extracts rather than unspecified proanthocyanidins.

Overall, the evidence is moderate (rated 3/5) due to limitations in sample sizes, variability in extract standardization, and a relative scarcity of large-scale, long-term studies. Nonetheless, the scientific rationale is rooted in both mechanistic studies and clinical trials, supporting the use of proanthocyanidins for venous health, particularly as an adjunct to other therapies.

More about Proanthocyanidin (unspecified)
More about Veins

Products containing Proanthocyanidin (unspecified)

We currently have no products on Vitabase that contain this ingredient.