Evidence supporting the use of: Proanthocyanidins
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Proanthocyanidins, particularly those derived from grape seeds (grape seed extract), have scientific evidence supporting their use for vein health. These compounds are a type of flavonoid known for their antioxidant properties and their ability to strengthen blood vessel walls. Multiple randomized controlled trials (RCTs) and meta-analyses suggest that proanthocyanidins can improve symptoms of chronic venous insufficiency (CVI), a condition where veins have problems sending blood from the legs back to the heart. Clinical studies have shown that supplementation with proanthocyanidins reduces leg swelling, heaviness, and discomfort associated with CVI.

The proposed mechanisms include enhanced capillary strength, reduced capillary permeability, and protection of vascular endothelium from oxidative damage. A 2016 meta-analysis published in Phytotherapy Research concluded that grape seed proanthocyanidin extract is effective and well-tolerated in reducing symptoms of CVI. Additionally, the European Medicines Agency acknowledges the use of proanthocyanidin-rich extracts for treating venous disorders.

While more large-scale studies would be valuable, current evidence supports the use of proanthocyanidins for promoting vein health, particularly in individuals with mild to moderate venous insufficiency. However, these supplements should not replace medical treatment for severe venous conditions.

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