Evidence supporting the use of: Proanthocyanidins (unspecified)
For the body system: Veins

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, particularly those derived from grape seed extract and pine bark (such as Pycnogenol®), have been studied for their effects on the venous system. These compounds are potent flavonoid antioxidants that help protect vascular endothelial cells and support capillary integrity. Research indicates that proanthocyanidins can reduce capillary permeability and fragility, which is relevant in conditions such as chronic venous insufficiency (CVI) and varicose veins.

Several randomized controlled trials and meta-analyses have reported that supplementation with proanthocyanidins can lead to a reduction in symptoms associated with CVI, including leg swelling (edema), heaviness, and discomfort. The proposed mechanisms include antioxidant activity, inhibition of enzymes that degrade the extracellular matrix, and improvement of venous tone. In Europe, grape seed proanthocyanidin extracts are recognized as supportive treatments for venous disorders.

However, while the evidence is promising, it is not entirely consistent and some studies have methodological limitations, such as small sample sizes or short durations. The ingredient's use in venous support is therefore backed by moderate scientific evidence, but further large-scale clinical trials are needed to confirm its efficacy and establish optimal dosing protocols.

More about Proanthocyanidins (unspecified)
More about Veins

Other body systems supported by Proanthocyanidins (unspecified)

Arteries
Blood
Capillaries
Circulatory System
Gums
Heart
Immune System
Skin
Urinary System
Veins

Products containing Proanthocyanidins (unspecified)

We currently have no products on Vitabase that contain this ingredient.