Evidence supporting the use of: Ruscogenin
For the body system: Veins

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ruscogenin is a steroidal sapogenin found in the plant Ruscus aculeatus (Butcher’s Broom), which has a long history in traditional European medicine for supporting venous health. Scientifically, ruscogenin is considered one of the main active compounds responsible for the plant’s vascular effects. Several studies have evaluated extracts of Butcher’s Broom, standardized for ruscogenin, in the management of chronic venous insufficiency (CVI) and related symptoms such as leg heaviness, swelling, and discomfort. Proposed mechanisms include vasoconstriction, anti-inflammatory activity, and the reduction of capillary permeability. Randomized, placebo-controlled clinical trials and meta-analyses suggest moderate efficacy in improving symptoms of CVI, although most studies use whole plant extracts rather than isolated ruscogenin. The European Medicines Agency (EMA) recognizes the traditional use of Butcher’s Broom extracts for relief of discomfort and heaviness of legs related to minor venous circulatory disturbances. However, while animal and in vitro studies have confirmed anti-inflammatory and venotonic actions of ruscogenin, high-quality clinical trials specifically on the isolated compound are limited. Thus, its use is scientifically supported primarily through studies on extracts containing ruscogenin, with moderate evidence for venous support, rather than robust evidence for ruscogenin alone.

More about Ruscogenin
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Other body systems supported by Ruscogenin

Arteries
Capillaries
Circulatory System
Lymphatics
Veins

Products containing Ruscogenin

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