Evidence supporting the use of: 17beta-(1-ketoethyl)-androstane-3-one, 17a-ol
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

17beta-(1-ketoethyl)-androstane-3-one, 17a-ol refers to the synthetic anabolic steroid oxandrolone. Oxandrolone is an orally active anabolic steroid derived from dihydrotestosterone. Its primary medical use is in the treatment of conditions associated with involuntary weight loss, such as wasting syndromes due to chronic infections (e.g., HIV/AIDS), severe trauma, long-term corticosteroid therapy, or recovery from extensive surgery and burns.

Scientific evidence supports oxandrolone’s efficacy in promoting weight gain and preserving lean body mass in catabolic states. Multiple randomized controlled trials and clinical studies have demonstrated that oxandrolone can increase muscle mass and strength, especially in patients with HIV-associated wasting and those recovering from severe burns. For example, a pivotal study published in the New England Journal of Medicine (1999) showed significant improvements in lean body mass among HIV patients treated with oxandrolone compared to placebo. Additionally, a systematic review in Drugs (2008) concluded that oxandrolone is effective for increasing weight and muscle mass in various catabolic conditions.

However, while there is consistent evidence supporting its anabolic effects, concerns about potential side effects (e.g., liver toxicity, lipid profile changes, endocrine disturbances) necessitate careful clinical supervision. Overall, oxandrolone’s use in treating wasting is scientifically validated but should be reserved for appropriate clinical situations where benefits outweigh the risks.

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Other health conditions supported by 17beta-(1-ketoethyl)-androstane-3-one, 17a-ol

Wasting

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