Evidence supporting the use of: 2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one is known as mestanolone, a synthetic anabolic androgenic steroid (AAS). The scientific rationale for its use in treating or supporting wasting (such as that associated with chronic illness, trauma, or aging) derives from its anabolic properties. Anabolic steroids like mestanolone can promote protein synthesis and muscle mass retention or gain, which are critical in combating catabolic states that lead to muscle wasting. Historical clinical use of AAS for conditions such as cachexia, HIV-associated wasting, and sarcopenia is documented, though mestanolone itself is less commonly studied compared to other agents such as oxandrolone, nandrolone, or testosterone derivatives.

The evidence supporting mestanolone specifically is limited; most clinical trials and regulatory approvals focus on other anabolic steroids. However, the pharmacological class demonstrates moderate efficacy in improving nitrogen balance, muscle mass, and sometimes functional outcomes in patients experiencing wasting. The main limitation is the risk profile, as AAS can cause significant adverse effects, including liver toxicity, lipid disturbances, hormonal suppression, and behavioral changes—mestanolone’s 17α-alkylation increases hepatic risk.

In summary, while there is scientific basis for the use of anabolic steroids in wasting syndromes, direct high-quality evidence for mestanolone is sparse. Its use is supported more by class effect than robust mestanolone-specific clinical trials, justifying a moderate evidence rating.

More about 2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one
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Other health conditions supported by 2a, 17a-dimethyl-17b-hydroxy-5a-androstan-3-one

Body Building
Wasting

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