Amino acid blends or complexes are scientifically validated for use in the support and treatment of wasting conditions, such as those seen in cachexia, sarcopenia, or malnutrition associated with chronic illnesses (e.g., cancer, HIV/AIDS, chronic kidney disease). Wasting is characterized by significant loss of muscle mass and body weight, often resulting from an imbalance between protein synthesis and degradation. Clinical studies have demonstrated that supplementation with essential amino acids, especially branched-chain amino acids (BCAAs) like leucine, can stimulate muscle protein synthesis, reduce muscle breakdown, and help preserve lean body mass in individuals experiencing wasting. Randomized controlled trials and meta-analyses have shown that amino acid supplementation can lead to improvements in muscle mass, strength, and sometimes physical function in patients with wasting syndromes.

Guidelines from organizations such as the European Society for Clinical Nutrition and Metabolism (ESPEN) recommend amino acid supplementation as part of nutritional support in patients at risk of or experiencing malnutrition and wasting. While the magnitude of benefit varies depending on the underlying disease and patient condition, the mechanistic rationale (amino acids as building blocks of protein synthesis) and clinical outcomes support their use. However, while there is robust evidence for efficacy, not all studies demonstrate significant functional improvements, and the optimal formulation and dosing remain under investigation.