Evidence supporting the use of: Andarine
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Andarine (also known as S-4) is a selective androgen receptor modulator (SARM) that has been investigated for its potential in treating muscle wasting (cachexia) associated with conditions such as cancer, osteoporosis, and age-related muscle loss. Preclinical studies, primarily in animal models, have demonstrated that Andarine can increase lean body mass, improve muscle strength, and decrease fat mass without the significant androgenic side effects associated with traditional anabolic steroids.

Despite promising results in animal studies, there is a lack of large-scale, peer-reviewed clinical trials in humans supporting Andarine’s efficacy and safety for the treatment of muscle wasting. Most human data are limited to small studies or anecdotal reports, and Andarine has not received regulatory approval for medical use in this context. Nevertheless, its mechanism—binding to androgen receptors in muscle and bone tissue—provides a rational scientific basis for its potential utility in muscle wasting disorders.

In summary, while there is a scientific rationale and some preclinical evidence supporting Andarine’s use for muscle wasting, the absence of robust clinical data limits the strength of this evidence. Therefore, its use for this condition remains experimental and unsupported by high-quality human studies.

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Other health conditions supported by Andarine

Muscle Tone (lack of)
Wasting

Products containing Andarine

We currently have no products on Vitabase that contain this ingredient.