Corn protein, primarily in the form of zein, is a plant-based protein source used in nutritional interventions for conditions involving wasting, such as protein-energy malnutrition and cachexia. The scientific rationale for its use is based on the need to provide adequate protein to support muscle maintenance and recovery in individuals experiencing wasting. Several studies have demonstrated that protein supplementation, including those derived from plant sources like corn, can help improve nitrogen balance, muscle mass, and overall nutritional status in malnourished patients. Corn protein is relatively high in some essential amino acids, but it is limited in lysine and tryptophan compared to animal proteins. Nevertheless, when combined with other protein sources or fortified, corn protein can contribute to meeting total protein requirements.

The evidence for using corn protein specifically (as opposed to general protein supplementation) in wasting is moderate but not as robust as for animal-based proteins or soy. Some clinical nutrition guidelines acknowledge the role of plant proteins, including corn, especially in resource-limited settings or for individuals with dietary restrictions. However, the quality and biological value of corn protein are lower compared to animal proteins, which may limit its effectiveness unless dietary adjustments are made. In summary, while the use of corn protein in treating or supporting wasting is scientifically grounded, its efficacy depends on dietary context, formulation, and the presence of complementary amino acid sources.