Evidence supporting the use of: Creatine-leucine
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine and leucine are both well-studied supplements with roles in muscle metabolism, and there is scientific evidence supporting their use to counteract muscle wasting (also known as cachexia or sarcopenia), especially in certain patient populations. Creatine supplementation has been shown in multiple clinical trials to help increase muscle mass, strength, and function, particularly in older adults and patients with muscle-wasting conditions. Creatine supports ATP regeneration in muscle cells, facilitating energy availability during periods of muscle contraction and recovery.

Leucine is an essential branched-chain amino acid known to stimulate muscle protein synthesis by activating the mTOR pathway. Supplementation with leucine, either alone or as part of protein mixtures, has been shown to reduce muscle loss and promote muscle protein accretion in various populations, including the elderly and those experiencing immobilization or chronic illness.

When combined, creatine and leucine may have additive or synergistic effects in supporting muscle protein synthesis and reducing muscle breakdown, which is the physiological basis for their use in treating or preventing wasting. Several studies have investigated their combined use in clinical and sports settings, showing improvements in muscle mass and function. While more research is needed to further establish optimal dosing and populations, the current body of evidence provides a strong scientific rationale for the use of creatine and leucine in managing muscle wasting.

More about Creatine-leucine
More about Wasting

Other health conditions supported by Creatine-leucine

Athletic and Exercise Aids
Fatigue
Muscle Tone (lack of)
Muscular Dystrophy
Wasting

Products containing Creatine-leucine

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