Evidence supporting the use of: Creatine Malate
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine malate, a compound formed from creatine and malic acid, is used as a dietary supplement primarily to enhance muscle energy metabolism. Wasting conditions, such as those associated with muscle atrophy, cachexia, or sarcopenia, involve the loss of muscle mass and strength. There is scientific evidence supporting the use of creatine supplementation (most commonly in the form of creatine monohydrate but also in other forms like creatine malate) for attenuating muscle loss in certain populations. Multiple clinical studies and meta-analyses have demonstrated that creatine supplementation, when combined with resistance training, can improve muscle mass and strength in older adults and in patients with neuromuscular diseases, such as muscular dystrophy. Some studies have also explored its use in conditions like HIV-associated wasting and cancer cachexia, with mixed results. The majority of research focuses on creatine monohydrate; direct studies on creatine malate are fewer, but the mechanisms and expected benefits are similar due to the shared creatine component. The evidence is strongest for benefits when creatine is paired with exercise interventions. Overall, while creatine is not a cure for wasting conditions, there is moderate scientific validation for its use as a supportive adjunct to resistance training in maintaining or increasing muscle mass in individuals at risk of muscle wasting.

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