Evidence supporting the use of: Creatine phosphate
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine phosphate (also known as phosphocreatine) supplementation is supported by scientific evidence for its role in attenuating muscle wasting (cachexia) associated with various conditions, such as muscular dystrophies, aging (sarcopenia), and chronic diseases. Creatine is a naturally occurring compound in muscle cells that helps rapidly regenerate adenosine triphosphate (ATP) during high-energy demand, thus supporting muscle function and strength. Multiple randomized controlled trials and meta-analyses have shown that creatine supplementation can increase lean body mass, improve muscle strength, and enhance physical performance in both healthy individuals and patients experiencing muscle wasting due to immobilization, aging, or specific diseases like muscular dystrophy.

However, while creatine’s effects on muscle mass and strength are consistently observed, direct evidence for its efficacy in treating clinical cachexia or severe wasting syndromes (e.g., cancer cachexia, advanced heart failure) remains limited or mixed. Some clinical trials in patients with neuromuscular disorders and elderly populations report modest benefits in muscle mass and function, but other studies show no significant effect on disease progression or functional outcomes. The overall safety profile of creatine is well-established, making it a feasible adjunct to resistance exercise in supportive care for wasting. Nevertheless, more high-quality, large-scale clinical trials are needed to determine its definitive therapeutic potential in pathological wasting conditions.

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