Evidence supporting the use of: Glucose
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glucose is scientifically validated as a key intervention in the management of wasting, especially in clinical settings involving malnutrition, cachexia, or severe undernutrition. Wasting, characterized by significant involuntary weight loss and muscle mass depletion, often results from inadequate caloric and nutrient intake. Glucose, as a simple carbohydrate, provides an immediate source of energy required for essential metabolic processes and tissue repair. In individuals suffering from wasting, the body’s glycogen stores are depleted, and catabolism of protein and fat is accelerated to meet energy needs. Administering glucose—either orally, enterally, or intravenously—can rapidly restore blood glucose levels, spare protein from breakdown, and support anabolic processes.

Clinical protocols, such as those used in the treatment of severe acute malnutrition (SAM) in children, often include glucose-containing solutions to manage hypoglycemia—a common and life-threatening complication of wasting. Glucose is also a primary component of refeeding regimens and total parenteral nutrition (TPN) for patients unable to eat. Multiple studies and treatment guidelines from organizations like the World Health Organization (WHO) support the use of glucose as an essential part of nutritional rehabilitation, emphasizing its role in stabilizing metabolism and supporting recovery. Thus, its use in treating wasting is grounded in robust scientific evidence and is standard in medical practice.

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