Evidence supporting the use of: Hydrolyzed protein (unspecified)
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydrolyzed protein is scientifically used and studied for the nutritional management of wasting conditions, such as those seen in chronic illnesses (e.g., cancer cachexia, HIV/AIDS, severe malnutrition, and other catabolic states). Wasting typically involves loss of muscle mass and protein stores. Hydrolyzed proteins are proteins that have been enzymatically broken down into peptides and amino acids, making them easier to digest and absorb compared to intact proteins. Scientific studies suggest that hydrolyzed proteins may be particularly beneficial in patients with compromised digestion or absorption, as seen in many wasting conditions, because of their improved bioavailability and reduced allergenicity. Clinical trials and meta-analyses indicate that hydrolyzed proteins can support nitrogen balance and muscle protein synthesis more effectively in some populations compared to whole proteins, thereby helping mitigate muscle loss. For example, they are commonly included in specialized oral nutritional supplements and enteral formulas designed for malnourished or at-risk individuals. However, while there is a sound mechanistic rationale and supportive data from nutritional intervention studies, the overall quality of evidence is moderate, as many studies are small or involve heterogeneous patient groups. There is consensus in clinical nutrition guidelines that hydrolyzed proteins are appropriate for patients with wasting and impaired digestion, but not unequivocal evidence that they are superior in all cases.

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