Relationship: Wasting and l-leucine

Evidence supporting the use of: L-leucine
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

L-leucine is one of the three branched-chain amino acids (BCAAs) and has been extensively studied for its role in muscle protein synthesis. Scientific evidence supports its use in the management of wasting conditions, such as sarcopenia (age-related muscle loss), cachexia (muscle wasting associated with chronic illness), and other forms of muscle atrophy. L-leucine acts as a key regulator of the mTOR (mechanistic target of rapamycin) pathway, which stimulates muscle protein synthesis. Clinical studies have demonstrated that supplementation with L-leucine, either alone or as part of a BCAA or protein supplement, can enhance muscle protein synthesis rates, particularly in elderly individuals or those experiencing catabolic stress. In cases of wasting, adequate leucine intake may help preserve lean body mass, support recovery, and improve functional outcomes. While the effect size can vary and the optimal dosing is still a topic of research, the overall scientific consensus is that L-leucine is beneficial in supporting muscle mass retention and mitigating the effects of muscle wasting, especially when combined with resistance exercise and adequate protein intake. It is important to note that while L-leucine supplementation is generally safe, it should be used as part of a comprehensive treatment plan under medical supervision, especially in individuals with compromised kidney function or other underlying health concerns.

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Other health conditions supported by L-leucine

Athletic and Exercise Aids
Body Building
Energy (lack of)
Fatigue
Muscle Tone (lack of)
Surgery (healing from)
Wasting
Weight Loss

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Evidence supporting the use of: L-leucine
For the health condition: Wasting

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Other ingredients used for Wasting

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Evidence supporting the use of: L-leucineFor the health condition: Wasting

Table of Contents

Synopsis

Other ingredients used for Wasting

Other health conditions supported by L-leucine

Products containing L-leucine

Evidence supporting the use of: L-leucine
For the health condition: Wasting