Evidence supporting the use of: Lysine alpha-ketoisocaproate
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lysine alpha-ketoisocaproate (Lysine-AKIC or α-ketoisocaproic acid) has been investigated for its potential use in treating or supporting muscle wasting (cachexia), particularly in clinical contexts such as chronic kidney disease, liver failure, or severe illness. The rationale for its use is based on its function as a keto acid analog of the essential amino acid leucine, which allows it to be transaminated to leucine in the body without contributing to nitrogen load. This property is especially valuable in patients with compromised kidney function, where excess nitrogen from protein breakdown can exacerbate uremia. Several studies and clinical guidelines, especially in nephrology, have incorporated keto acid analogs, including lysine alpha-ketoisocaproate, into low-protein diets for patients with chronic kidney disease to prevent or mitigate protein-energy wasting. Randomized controlled trials and meta-analyses suggest that supplementation with keto acid analogs can help maintain or improve nutritional status and muscle mass in these populations, though the evidence is not universally strong and may vary depending on patient demographics and baseline nutritional status. However, outside of chronic kidney disease, the evidence for lysine alpha-ketoisocaproate in general wasting syndromes is less robust. More research is needed to clarify its efficacy in other forms of cachexia, such as cancer or AIDS-related wasting. Overall, the use of lysine alpha-ketoisocaproate in wasting is supported by moderate scientific evidence, primarily in specialized clinical populations.

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Other health conditions supported by Lysine alpha-ketoisocaproate

Wasting

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