Evidence supporting the use of: Arginine Creatine
For the health condition: Weight Gain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Arginine Creatine is a combination of two compounds: L-arginine, an amino acid, and creatine, a well-known ergogenic supplement. The use of creatine for supporting weight gain—specifically, increases in lean body mass—is strongly supported by scientific evidence. Numerous clinical trials have demonstrated that creatine supplementation, especially when combined with resistance training, leads to significant increases in muscle mass and overall body weight. This effect is primarily due to enhanced water retention in muscle cells and increased synthesis of muscle proteins. L-arginine, while less directly implicated in weight gain, is often included for its potential to increase nitric oxide production, which may improve exercise performance and thus indirectly contribute to muscle growth.

Although most studies focus on creatine monohydrate rather than the arginine-creatine combination, the underlying mechanisms suggest synergistic effects could be possible. However, the evidence specifically for the combination is less robust than for creatine alone. The overall body of research supports creatine as an effective, evidence-based supplement for athletes or individuals seeking to increase muscle mass and body weight in conjunction with resistance training. Arginine's contribution to weight gain is less clear, but its use in combination products is common in the sports nutrition industry.

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