Evidence supporting the use of: Glucose
For the health condition: Weight Gain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glucose is a simple sugar and the primary source of energy for the human body. Its use in supporting or treating weight gain is scientifically validated, primarily in clinical settings where individuals are unable to consume adequate calories orally due to illness, surgery, or severe malnutrition. In such cases, glucose is administered intravenously (as dextrose solutions) or orally to provide rapid and easily digestible caloric support. This helps prevent catabolism and promotes weight stabilization or gain, particularly in patients with conditions like anorexia, cachexia, or after significant trauma. Beyond clinical contexts, the role of glucose in weight gain is straightforward from a physiological standpoint: excess glucose, when consumed beyond the body's immediate energy needs, is converted to glycogen and, when glycogen stores are full, to fat. Thus, high glucose intake can contribute to weight gain, which is the basis for its inclusion in high-calorie supplements and drinks. However, glucose is not typically recommended as a stand-alone intervention for intentional, healthy weight gain in the general population due to potential adverse effects, such as increased risk of insulin resistance, diabetes, and cardiovascular disease when consumed in excess. Most dietary guidelines recommend balanced macronutrient intake for weight gain rather than isolated glucose supplementation. In summary, glucose is scientifically used for weight gain in specific medical situations requiring rapid caloric input, but its use for routine, healthy weight gain lacks strong endorsement outside of these contexts.

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