Evidence supporting the use of: Muscle
For the health condition: Weight Gain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Muscle, in the context of weight gain, usually refers to the process of increasing skeletal muscle mass through resistance training and adequate nutritional support, rather than an herbal or pharmaceutical ingredient. The use of muscle-building strategies to support or treat weight gain is strongly backed by scientific evidence, particularly for individuals who are underweight, recovering from illness, or aiming to improve body composition. Numerous clinical studies have demonstrated that resistance exercise, combined with sufficient protein and caloric intake, leads to significant increases in muscle mass and overall body weight. For example, meta-analyses indicate that structured resistance training results in meaningful muscle hypertrophy and weight gain in both healthy adults and clinical populations such as the elderly or those with cachexia. Muscle gain through exercise is also correlated with improvements in metabolic health, strength, and physical function. Therefore, promoting muscle growth is a scientifically validated and widely recommended approach to healthy weight gain, especially as opposed to gaining weight primarily through increased fat mass. While pharmacological agents and supplements may sometimes play a supporting role, the cornerstone of evidence-based weight gain therapy is muscle-building through resistance exercise and nutrition.

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