Evidence supporting the use of: Proprietary Blend (Amino Acid/Protein)
For the health condition: Weight Gain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proprietary blends of amino acids and proteins are commonly used in dietary supplements aimed at supporting weight gain, particularly in the context of muscle building and athletic performance. Scientific evidence suggests that increased protein and essential amino acid intake can support muscle protein synthesis, especially when combined with resistance training. Several randomized controlled trials and meta-analyses have shown that protein supplementation can enhance muscle mass and overall body weight in individuals engaged in strength training or those who are underweight due to insufficient protein intake (Morton et al., 2018). Essential amino acids, particularly leucine, play a critical role in triggering muscle protein synthesis. However, the strength of the evidence is moderate (rated 3/5) because the efficacy of "proprietary blends" varies widely based on their specific composition, quality, and dosing. Not all blends are created equal, and some may include suboptimal amounts or forms of protein and amino acids. Additionally, while protein and amino acid supplementation can support lean mass gains, their effect on overall weight gain (including fat mass) is more limited and dependent on overall caloric surplus. In summary, there is scientific validation for the use of protein and amino acid supplements to support weight gain, primarily through increased muscle mass, but the degree of benefit depends on the blend's composition and the user's overall diet and exercise regimen.

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