Evidence supporting the use of: Somatropin
For the health condition: Weight Gain

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Somatropin is a recombinant human growth hormone (rhGH) that is scientifically validated for use in promoting weight gain in specific clinical situations, primarily those involving growth hormone deficiency or catabolic states. In individuals with growth hormone deficiency (both children and adults), somatropin has been shown to increase lean body mass, reduce fat mass, and improve overall body composition. Its efficacy is well-established in conditions such as Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, and in patients with HIV-associated wasting. Clinical trials have demonstrated that somatropin therapy can increase muscle mass and support weight gain in these populations by stimulating protein synthesis, enhancing lipolysis, and promoting retention of nitrogen, minerals, and electrolytes.

However, somatropin is not indicated or supported for general weight gain in healthy individuals or in those seeking to gain weight for aesthetic or athletic purposes. Its use is strictly regulated due to potential side effects, including edema, arthralgia, insulin resistance, and increased risk of certain malignancies. The rating of 4 reflects strong evidence for weight gain and body composition improvement in medically indicated contexts, but not for general or non-clinical use.

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