Evidence supporting the use of: Alpha-cyclodextrin
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-cyclodextrin is a soluble dietary fiber derived from starch. It is marketed as a weight management aid, primarily because of its purported ability to bind dietary fat and reduce fat absorption. Several clinical studies have examined its effects on lipid metabolism and weight loss, but the evidence is mixed and generally modest in effect size.

A few randomized, placebo-controlled trials have shown that alpha-cyclodextrin can reduce postprandial triglyceride levels after high-fat meals, suggesting some interference with fat absorption. However, when it comes to weight loss, the results are less consistent. Some small studies (often funded by manufacturers) report minor reductions in body weight or waist circumference over several months of supplementation, but these effects are not robustly replicated in larger, independent trials.

Systematic reviews and meta-analyses note that while alpha-cyclodextrin may influence lipid profiles, its direct effect on weight loss in humans is limited and not clinically significant. The ingredient is recognized as safe by regulatory agencies when used as a fiber supplement, but its weight loss benefits remain unproven. Overall, there is some scientific investigation, but the strength and consistency of evidence supporting alpha-cyclodextrin as an effective weight loss aid are low.

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