Evidence supporting the use of: Alpha-ketoglutarate (AKG)
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Alpha-ketoglutarate (AKG) is a key intermediate in the Krebs (citric acid) cycle, which is essential for cellular energy production. Its use as a dietary supplement for weight loss is primarily based on preliminary scientific rationale rather than strong clinical evidence. The hypothesis is that, by supporting cellular metabolism and energy production, AKG might increase fat oxidation or influence metabolic rate, thus aiding weight loss. Additionally, some animal studies have suggested that AKG supplementation can impact body composition, possibly by modulating amino acid metabolism or influencing hormones involved in muscle preservation and fat breakdown.

However, the direct evidence supporting AKG for weight loss in humans is minimal. A few small-scale studies and preclinical (animal) research have indicated potential benefits in muscle preservation during calorie restriction or exercise, but robust, well-controlled human trials showing significant or consistent weight loss effects are lacking. Most clinical studies involving AKG focus on its use in catabolic states, such as during illness or after surgery, rather than in healthy individuals attempting weight loss.

In summary, while there is a scientific rationale and some early research suggesting a possible role for AKG in supporting weight management, the overall quality and quantity of evidence is low. More rigorous human studies are needed before AKG can be confidently recommended for weight loss.

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