Evidence supporting the use of: Capsiate
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Capsiate is a non-pungent analog of capsaicin, naturally found in "CH-19 Sweet" peppers. Its primary use in weight loss is supported by scientific evidence, mainly from animal studies and a limited number of human trials. Capsiate has been shown to increase energy expenditure and fat oxidation through stimulation of the sympathetic nervous system, similar to capsaicin but without the spicy sensation. Several randomized, placebo-controlled trials in humans have demonstrated modest increases in resting metabolic rate and fat oxidation after capsiate supplementation, with daily doses ranging from 3-9 mg. However, the observed effects on actual weight loss are generally small and may not reach clinical significance in the short term.

Meta-analyses and systematic reviews suggest that capsiate can lead to a slight increase in calorie burning (about 50 kcal/day), which could contribute to weight control over time if maintained. The European Food Safety Authority (EFSA) recognizes these metabolic effects but considers the evidence insufficient for health claims related to weight loss in the general population. Side effects are minimal, and the compound is generally well tolerated.

In summary, there is scientific evidence supporting capsiate's thermogenic and fat oxidation effects, but the magnitude of weight loss is modest. More long-term and large-scale clinical trials are needed to confirm its efficacy for weight reduction in diverse populations.

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Products containing Capsiate

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