Evidence supporting the use of: Cardarine
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cardarine (also known as GW501516) is a peroxisome proliferator-activated receptor delta (PPARδ) agonist originally developed for potential treatment of metabolic and cardiovascular diseases. The interest in Cardarine for weight loss and fat reduction stems from preclinical animal studies showing that it can increase fatty acid oxidation, improve lipid profiles, and enhance physical endurance. In rodent models, Cardarine has been found to shift energy metabolism towards increased fat burning, leading to reduced fat mass and improved exercise performance. However, there is a lack of robust, peer-reviewed clinical trials in humans that confirm these effects for weight loss or obesity management. Most of the human data comes from anecdotal reports or indirect findings rather than well-controlled studies. It is important to note that Cardarine is not approved for human use by regulatory agencies (such as the FDA) due to concerns about safety, including findings of cancer development in animal studies during long-term exposure. While the mechanistic rationale for increased fat oxidation has some scientific basis based on preclinical data, the evidence in humans is insufficient and does not meet the standards for clinical validation. Thus, while there is a scientific basis for its action, the supporting evidence for weight loss efficacy in humans is weak and primarily limited to animal research.

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Products containing cardarine

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