Evidence supporting the use of: Evodiamine
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Evodiamine is an alkaloid extracted from the fruit of Evodia rutaecarpa, a plant used in traditional Chinese medicine. In recent years, evodiamine has been investigated for potential weight loss and anti-obesity effects, primarily in preclinical models. Several animal studies have demonstrated that evodiamine can reduce body weight gain and fat accumulation in rodents fed high-fat diets. Proposed mechanisms include increased energy expenditure, enhanced thermogenesis, inhibition of adipogenesis, and modulation of appetite-regulating pathways. For example, research published in Obesity Research (2003) found that evodiamine increased thermogenesis and reduced fat mass in mice. Additional studies suggest possible effects on metabolic enzymes and brown adipose tissue activation. However, scientific validation in humans is very limited. There are currently no well-controlled, peer-reviewed clinical trials in humans that confirm evodiamine’s efficacy or safety for weight loss. Most of the evidence comes from cell culture and animal experiments, and the translation of these results to humans is uncertain. In summary, while there is some preliminary scientific evidence from laboratory studies that supports the potential weight loss effects of evodiamine, robust clinical data in humans is lacking. Therefore, its use for this purpose is only weakly supported by current scientific research.

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