Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coleus forskohlii (now known as Plectranthus barbatus), and specifically its active compound forskolin, has been marketed for weight loss. The scientific basis for this use is modest and primarily stems from a handful of small clinical trials. Forskolin is thought to stimulate the enzyme adenylate cyclase, increasing levels of cyclic AMP (cAMP) in cells, which may enhance lipolysis (fat breakdown) and thermogenesis.

A few human studies have investigated forskolin’s effect on body composition. One randomized, double-blind, placebo-controlled study in overweight and obese men found that 12 weeks of forskolin supplementation (250 mg of 10% forskolin extract twice daily) resulted in a significant decrease in body fat percentage, but not in total body weight compared to placebo. Another study in overweight women did not find significant effects on weight loss but noted a reduction in fatigue and appetite.

Overall, the evidence is limited by small sample sizes, short study durations, and sometimes conflicting results. Meta-analyses and systematic reviews generally conclude that forskolin may have a mild effect on body fat reduction, but not enough to recommend it as a reliable or primary weight loss intervention. Its use for weight loss has some scientific rationale, but robust clinical validation is lacking, justifying a moderate evidence rating.

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