Grains of Paradise (Aframomum melegueta) is a spice from West Africa traditionally used for various medicinal purposes, but its association with weight loss is primarily based on recent scientific interest rather than long-standing traditional use. Modern research has explored its potential effects on energy expenditure and fat loss. Several small-scale human studies have provided preliminary evidence suggesting that Grains of Paradise extract may increase thermogenesis (heat production) and energy expenditure, which could support weight management efforts.

For example, a 2013 randomized, double-blind, placebo-controlled trial published in Lipids in Health and Disease found that supplementation with Grains of Paradise extract increased whole-body energy expenditure and reduced visceral fat in healthy, non-obese women over four weeks. Another study in men indicated a mild increase in energy expenditure and fat oxidation following a single dose. These effects are attributed to the activation of brown adipose tissue by compounds such as 6-paradol present in the spice.

However, the evidence remains limited due to small sample sizes, short study durations, and a lack of long-term clinical trials. There is insufficient data to conclude large or sustained weight loss effects in diverse populations. Therefore, while there is some scientific basis for its use in weight management, the overall strength of evidence is modest.