Evidence supporting the use of: Ketone
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketones, particularly in the form of exogenous ketone supplements (such as ketone salts or esters), have been promoted as aids for weight loss. The rationale is largely based on the physiological effects of endogenous ketone production during a ketogenic (very low carbohydrate) diet, where the body produces ketones from fat as an alternative energy source, typically resulting in appetite suppression and fat loss. However, the scientific evidence for exogenous ketone supplements directly promoting weight loss is limited.

Several small studies indicate that ketone supplementation can increase blood ketone levels and may transiently suppress appetite, potentially reducing caloric intake. For example, a 2018 study published in Obesity found that ingestion of ketone esters reduced appetite hormones and subjective hunger ratings in healthy individuals. However, most clinical trials have not demonstrated significant or sustained weight loss attributable to exogenous ketones alone, independent of dietary changes.

In summary, while there is a plausible physiological basis and some early evidence that ketone supplements might modestly impact appetite or energy expenditure, robust clinical evidence supporting their use for significant or sustained weight loss is lacking. Most health authorities and systematic reviews conclude that exogenous ketones are not a substitute for calorie restriction or lifestyle modification in weight management. Therefore, the evidence rating stands at 2/5—some preliminary scientific data, but insufficient for strong clinical recommendations.

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