Evidence supporting the use of: Ketone (unspecified)
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis: Ketones, specifically exogenous ketone supplements (such as ketone esters or ketone salts), have attracted interest for their potential to support weight loss, mainly due to their role in ketogenic diets. Scientific evidence supporting their use for weight loss is limited and mixed. Some studies have shown that exogenous ketone supplements can increase blood ketone levels, mimicking a state of nutritional ketosis, which may suppress appetite and reduce food intake in the short term. A few small-scale clinical trials report modest reductions in appetite and hunger after ketone supplementation. However, robust clinical trials directly demonstrating significant or sustained weight loss due to exogenous ketones are lacking.

Most weight loss associated with ketones is indirectly attributed to ketogenic diets, which are low in carbohydrates and high in fats, leading the body to produce endogenous ketones for energy. These diets have been shown in several studies to result in weight loss, but the effect is likely due to reduced calorie intake and appetite suppression from ketosis, not from ketones themselves as supplements. Additionally, some preliminary studies suggest exogenous ketones may increase fat oxidation, but this has not consistently translated to fat loss in humans. Therefore, while there is some scientific rationale and preliminary evidence, the overall quality and quantity of evidence supporting exogenous ketones as a weight loss aid is currently low.

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