Evidence supporting the use of: Leucine
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Leucine is an essential branched-chain amino acid (BCAA) that has been studied for its potential role in supporting weight loss, primarily through its effects on muscle protein synthesis and metabolic regulation. Scientific research suggests that leucine can stimulate muscle protein synthesis via activation of the mTOR pathway, which may help preserve lean muscle mass during caloric restriction. This is significant because maintaining muscle mass can help sustain basal metabolic rate during weight loss interventions.

Some studies in both animals and humans indicate that leucine supplementation may contribute to reduced body fat and improved body composition, especially when combined with resistance training or high-protein diets. Leucine has also been shown to promote satiety, potentially reducing overall calorie intake. However, the direct effect of leucine supplementation on weight loss in humans is modest, and evidence is inconsistent. Most research supports leucine’s benefits in the context of protein-rich diets rather than as a standalone supplement for weight loss.

Overall, while there is a scientific rationale for leucine’s use in weight management—primarily via muscle preservation and satiety—current evidence is limited and not robust enough to support its use as a primary weight loss aid. More large-scale, long-term human studies are needed to establish its effectiveness and safety for this specific purpose.

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