Evidence supporting the use of: Polydextrose
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polydextrose is a synthetic polymer of glucose that is widely used as a low-calorie bulking agent and fiber supplement in food products. Scientific studies have investigated its effects on weight management, primarily due to its low energy value (about 1 kcal/g) and its capacity to promote satiety. Several randomized controlled trials and systematic reviews have shown that polydextrose can increase feelings of fullness and reduce subsequent calorie intake, which may indirectly support weight loss or weight management. For example, a 2012 study published in "Appetite" found that polydextrose supplementation reduced energy intake at subsequent meals. A 2020 meta-analysis in "Nutrients" concluded that polydextrose could modestly enhance satiety and reduce energy intake, though the effect sizes were generally small.

The mechanism is believed to involve delayed gastric emptying and modulation of gut hormones related to appetite regulation. Additionally, as a prebiotic fiber, polydextrose may favorably alter gut microbiota, potentially contributing to metabolic benefits. However, direct evidence linking polydextrose supplementation to clinically significant weight loss in humans is limited and inconsistent. Most studies focus on short-term effects on satiety or caloric intake rather than long-term weight outcomes. Therefore, while there is scientific validation for its potential role in supporting weight management, the overall strength of evidence is moderate and primarily supports its use as part of a calorie-controlled diet rather than as a standalone weight loss agent.

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