Evidence supporting the use of: Rauwolscine
For the health condition: Weight Loss

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rauwolscine is an alkaloid structurally similar to yohimbine, primarily acting as an alpha-2 adrenergic receptor antagonist. Its use in weight loss is supported by some scientific rationale, though evidence in humans is limited. By blocking alpha-2 adrenergic receptors, rauwolscine may increase norepinephrine release, promoting lipolysis (fat breakdown) and potentially increasing energy expenditure. This mechanism is theorized to help mobilize fat stores, especially in areas of stubborn fat.

However, most of the available evidence comes from mechanistic studies, animal research, and extrapolations from the effects of yohimbine. A handful of small human studies on yohimbine suggest modest fat loss effects, particularly in combination with exercise, but direct studies on rauwolscine itself in humans are scarce. No large, high-quality randomized controlled trials have specifically evaluated rauwolscine’s efficacy for weight loss.

In summary, rauwolscine's use for weight loss is scientifically plausible given its pharmacological action, but the clinical evidence is weak and largely indirect. Caution is advised due to possible side effects such as increased heart rate, blood pressure, and anxiety. It is not an evidence-based first-line treatment for weight loss, and more research is needed to confirm its efficacy and safety in humans.

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Other health conditions supported by Rauwolscine

Fat Metabolism (poor)
Weight Loss

Products containing Rauwolscine

We currently have no products on Vitabase that contain this ingredient.