Evidence supporting the use of: Bacoside
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacoside is a primary active compound found in Bacopa monnieri, a traditional Ayurvedic herb. While its use in Ayurveda for cognitive enhancement and stress reduction is well-documented historically, modern scientific studies have begun to investigate its effects on anxiety and related symptoms (such as "worry"). Several preclinical and clinical studies suggest that Bacopa extracts, standardized for bacosides, may have anxiolytic (anxiety-reducing) effects. For example, randomized controlled trials in humans have reported modest reductions in anxiety scores and improvements in mood after several weeks of supplementation with Bacopa extracts. The proposed mechanism involves modulation of neurotransmitter systems, such as serotonin, and antioxidant effects on the brain. However, the quality and quantity of clinical evidence specifically targeting "worry" as a symptom or diagnosis remain limited. Most studies measure general anxiety or stress, with variable study designs and sample sizes. While the traditional use for mental calmness provides a basis for its application, and early scientific research is promising, robust clinical validation for the specific treatment or support of "worry" is lacking. Therefore, the evidence supporting bacoside's use for worry can be considered modest but not definitive.

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