Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Benegut perilla, a proprietary extract usually derived from the leaves of Perilla frutescens, is primarily used in traditional medicine, especially within East Asian herbal practices. For centuries, perilla has been used in Traditional Chinese Medicine (TCM) to address a variety of ailments, including digestive issues and symptoms related to emotional distress, sometimes described as "worry" or "anxiety" in modern terms. The rationale stems from TCM concepts in which perilla is thought to "move qi" and alleviate stagnation that may manifest as both physical and emotional discomfort. Historical records and pharmacopeias mention perilla leaves as a remedy for calming the mind and easing restlessness, which aligns with the modern interpretation of supporting individuals experiencing worry or mild anxiety. However, scientific validation for these uses remains limited. Some preclinical studies suggest that perilla extracts may exert mild anxiolytic (anxiety-reducing) effects, possibly due to modulation of neurotransmitter systems such as GABA, but robust clinical trials in humans are lacking. The proprietary nature of the "benegut perilla" formulation also means that evidence may not generalize to all perilla extracts. In summary, the use of benegut perilla to support or treat worry is grounded primarily in traditional use, with only preliminary scientific support. Until more rigorous clinical data are available, its efficacy for this purpose should be considered as having modest evidence, rooted mainly in tradition.

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