Evidence supporting the use of: Phosphatidyl inositol
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylinositol, often referenced alongside inositol, has garnered some scientific interest for its potential role in supporting mental health conditions such as anxiety and obsessive-compulsive disorder (OCD). Although "worry" is not a clinical diagnosis, it can be considered a symptom within the spectrum of anxiety disorders. Most research regarding inositol’s effects on psychological conditions has focused on myo-inositol, a naturally occurring isomer, rather than phosphatidylinositol specifically. Clinical studies have demonstrated that high doses of inositol (typically 12-18 grams per day) may reduce symptoms of anxiety and panic disorder, with some benefit seen in OCD as well. For example, a double-blind controlled trial published in the American Journal of Psychiatry (1995) found that inositol reduced panic attacks compared to placebo. However, phosphatidylinositol is a component of cell membranes and is not the same as free inositol or myo-inositol supplements.

There is limited direct evidence regarding the specific use of phosphatidylinositol for worry or anxiety, though it plays a role in cell signaling pathways that are related to neurotransmitter function. Thus, while there is a scientific rationale and some indirect evidence for inositol derivatives in supporting mood and reducing anxiety, the evidence supporting phosphatidylinositol specifically for “worry” is limited and not robust. The overall quality and quantity of evidence is modest, meriting a rating of 2 out of 5.

More about phosphatidyl inositol
More about Worry

Other health conditions supported by phosphatidyl inositol

Anxiety
Anxiety Disorders
Depression
Worry

Products containing phosphatidyl inositol

We currently have no products on Vitabase that contain this ingredient.