Evidence supporting the use of: Schisandrins
For the health condition: Worry

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schisandrins, the active lignans found in the fruit of Schisandra chinensis, have a long history of use in Traditional Chinese Medicine (TCM). Schisandra, known as "Wu Wei Zi," is traditionally used as an adaptogen—an agent believed to help the body resist the effects of stress and restore balance. In TCM, worry and emotional disturbances are often linked to imbalances in the heart and spleen. Schisandra has been used to "calm the spirit" and to nourish and stabilize these organs, thereby addressing symptoms such as anxiety, emotional instability, and excessive worry. The traditional rationale is rooted in the herb’s reputed ability to tonify Qi, calm the Shen (mind/spirit), and support overall resilience. However, scientific evidence for Schisandrins specifically treating worry or anxiety in humans is limited. A few preclinical studies suggest anxiolytic and neuroprotective effects of schisandrin compounds in animal models, possibly involving modulation of neurotransmitters and stress hormone responses. Despite these findings, robust clinical trials in humans are lacking. Thus, the use of Schisandrins for "worry" is primarily grounded in traditional medical systems rather than validated by high-quality scientific research.

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