Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has some scientific evidence supporting its use in reducing symptoms of worry and anxiety, though the overall strength of this evidence is moderate. B6 is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play roles in mood regulation. Several small clinical studies and observational research suggest that low levels of B6 may be associated with increased risk of anxiety and depressive symptoms. For example, a randomized controlled trial published in 2022 found that high-dose supplementation with B6 reduced self-reported anxiety in young adults compared to placebo. However, the effect size was modest, and the study sample was relatively small.

Other studies have shown that B6 supplementation, sometimes in combination with magnesium, can improve mood and reduce stress in certain populations, such as premenstrual women or individuals under chronic stress. Despite these findings, the evidence base is limited by small sample sizes and variability in study design. No large-scale, high-quality trials have definitively established B6 as an effective treatment for generalized anxiety or "worry." Thus, while the biological rationale is plausible and there are preliminary human data, more robust evidence is needed before Vitamin B6 can be considered a first-line or standalone treatment for worry or anxiety disorders.

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