Silicon, particularly in the form of silicone-based dressings and gels, is widely supported by scientific evidence for use in the treatment and support of wounds and sores. Silicone dressings—such as silicone gel sheets and foams—are commonly used in clinical practice, especially for managing scars, burns, chronic wounds, and pressure sores. The mechanism of action involves creating a semi-occlusive barrier that maintains a moist wound environment, reduces transepidermal water loss, and protects the wound from external contaminants. This environment is conducive to faster and optimal healing, as well as reduced risk of hypertrophic scarring and keloids.

Multiple randomized controlled trials and systematic reviews have demonstrated that silicone dressings are effective in improving wound healing outcomes and reducing scar formation, especially after surgical incisions or traumatic injuries. For example, a 2016 Cochrane review concluded that silicone gel sheeting is more effective than no treatment for the prevention and management of hypertrophic and keloid scars. Additionally, silicone dressings are valued for their atraumatic removal, which minimizes pain and tissue damage during dressing changes.

The use of topical silicon (silicone) as a wound treatment is thus grounded in robust clinical evidence, making it a first-line option for wound care specialists and surgeons. Its effectiveness is attributed primarily to its physical properties rather than any pharmacological activity of silicon itself.