Evidence supporting the use of: Alpha-lipoic acid
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Lipoic Acid (ALA) is an antioxidant that has been studied for its potential role in skin health, including its effects on wrinkles. Scientific evidence suggests that ALA may help reduce the appearance of wrinkles and improve skin texture, primarily due to its antioxidant properties and its ability to modulate inflammation and collagen synthesis. Topical formulations of ALA have been shown in some small clinical studies to improve skin roughness and reduce fine lines. For example, a double-blind, placebo-controlled trial by Beitner (2003) demonstrated that a 5% topical ALA cream led to a significant reduction in facial lines and skin roughness over 12 weeks compared to placebo.

ALA acts both in water- and fat-soluble environments, allowing it to penetrate various skin layers and neutralize free radicals generated by UV exposure—one of the primary causes of premature skin aging and wrinkle formation. Additionally, ALA may help regenerate other antioxidants such as vitamins C and E in the skin, further enhancing its protective effect.

However, the body of evidence is relatively modest in size and quality, mostly limited to small human trials and in vitro studies. There is still a need for larger, long-term studies to confirm its efficacy and safety for wrinkle reduction. Therefore, while there is some scientific rationale and early evidence supporting the use of ALA for wrinkles, the strength of evidence is moderate at best.

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