Evidence supporting the use of: Carnosine
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carnosine is a naturally occurring dipeptide composed of beta-alanine and histidine, found in high concentrations in muscle and brain tissues. Its use in supporting or treating wrinkles is primarily based on its antioxidant properties and its ability to inhibit the formation of advanced glycation end-products (AGEs), which contribute to skin aging and the formation of wrinkles. Scientific studies, mostly in vitro and in animal models, have demonstrated that carnosine can protect skin cells against oxidative stress and glycation, processes both implicated in skin aging. Some small clinical studies and topical formulations containing carnosine have suggested modest improvements in skin elasticity and reduction in fine lines, but robust, large-scale, placebo-controlled trials in humans are lacking. A 2012 review published in Skin Pharmacology and Physiology highlights carnosine’s antiglycation action and suggests potential for anti-aging skin care, though it notes that clinical evidence is preliminary. Another study by Hipkiss (2010) in Rejuvenation Research discusses carnosine’s theoretical benefits against skin glycation. Topical products containing carnosine are marketed for wrinkle reduction, but the evidence supporting their efficacy is limited and not universally accepted in dermatology. In summary, while there is a scientific rationale and some early evidence for carnosine’s use in wrinkle prevention, the strength of evidence is modest (2/5), and more rigorous clinical trials are needed to confirm its effectiveness in humans.

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Products containing Carnosine

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