Evidence supporting the use of: Flavanones
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids commonly found in citrus fruits such as oranges, lemons, and grapefruits. They have been studied for their antioxidant and anti-inflammatory properties, which are believed to contribute to skin health and potentially reduce the appearance of wrinkles. The rationale is that oxidative stress and chronic inflammation accelerate skin aging and wrinkle formation; thus, compounds that counteract these processes might help mitigate wrinkle development.

Some in vitro and animal studies indicate that flavanones can protect skin cells from oxidative damage and enhance collagen synthesis, both of which are relevant to wrinkle prevention. Small-scale human studies and topical formulations containing flavanone-rich extracts (such as hesperidin or naringenin) have demonstrated modest improvements in skin elasticity and reduction in wrinkle depth. However, these studies are limited in size and duration, and often use combinations of ingredients, making it difficult to attribute effects solely to flavanones.

While there is some scientific interest and preliminary evidence, robust clinical trials specifically investigating flavanones for wrinkle reduction are lacking. Therefore, the scientific validation is limited (rated 2/5), and more high-quality research is needed to confirm their efficacy for this purpose.

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Products containing flavanones

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