Evidence supporting the use of: Flavones
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a class of polyphenolic compounds found in various fruits, vegetables, and herbs, including parsley, celery, and chamomile. They are a subclass of flavonoids, which are well known for their antioxidant properties. Scientific interest has focused on the role of flavones in skin health, particularly in the context of aging and the formation of wrinkles. Experimental and clinical studies suggest that flavones can combat oxidative stress by neutralizing free radicals, which are believed to contribute to the breakdown of collagen and elastin in the skin—two proteins essential for skin elasticity and smoothness.

Some in vitro and animal studies have demonstrated that certain flavones (such as apigenin and luteolin) can reduce the expression of matrix metalloproteinases (MMPs), enzymes that degrade collagen in the skin. Additionally, flavones may inhibit inflammatory pathways that contribute to skin aging. There are also a few small human studies and clinical trials showing that topical or oral supplementation with flavone-rich plant extracts can modestly improve skin hydration, elasticity, and reduce wrinkle depth.

However, while these findings are promising, high-quality, large-scale clinical trials in humans are limited. The current level of evidence supporting the use of flavones specifically to treat or prevent wrinkles is moderate at best, justifying a rating of 2 on the evidence scale.

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Products containing flavones

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