Evidence supporting the use of: Polymethoxylated flavones
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polymethoxylated flavones (PMFs) are a group of citrus-derived flavonoids, most commonly found in the peels of sweet oranges and tangerines. In recent years, there has been growing scientific interest in their potential dermatological benefits, including their role in mitigating skin aging and the appearance of wrinkles. Several in vitro and animal studies indicate that PMFs possess anti-inflammatory, antioxidant, and UV-protective properties, all relevant to skin health and wrinkle prevention. For example, nobiletin and tangeretin, two prominent PMFs, have been shown to inhibit matrix metalloproteinase (MMP) activity in cultured skin cells, suggesting a mechanism for reducing collagen breakdown associated with wrinkle formation. Additionally, their antioxidant actions help neutralize free radicals generated by UV exposure, a key factor in extrinsic skin aging. However, direct clinical evidence in humans is limited. A few small pilot studies have examined topical or oral PMF preparations for improving skin elasticity or reducing wrinkle depth, with modest but promising results. Nevertheless, larger, well-controlled clinical trials are needed to confirm efficacy and establish optimal dosing regimens. In summary, while there is preliminary scientific support for the use of polymethoxylated flavones in wrinkle prevention or treatment, the current level of evidence is still emerging and should be interpreted with caution.

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