Evidence supporting the use of: Procyanidol
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Procyanidol, more accurately referred to as procyanidins or proanthocyanidins, are polyphenolic compounds present in a variety of plants, including grape seeds and pine bark. Their use in supporting or treating wrinkles is primarily based on their antioxidant properties. Scientific studies have shown that procyanidins can scavenge free radicals, reduce oxidative stress, and modulate inflammatory responses in the skin, which are factors implicated in skin aging and wrinkle formation. Some small clinical studies and in vitro experiments suggest that oral or topical administration of procyanidin-rich extracts may improve skin elasticity, hydration, and reduce wrinkle depth, likely by protecting collagen and elastin fibers from degradation.

However, the available evidence is limited: most studies have small sample sizes, short durations, or use formulations with multiple active ingredients, making it difficult to attribute effects solely to procyanidins. There is some positive data from randomized controlled trials involving grape seed extract and pine bark extract (Pycnogenol®), but these are not universally accepted as definitive. There is not yet high-quality, large-scale clinical research confirming the efficacy of procyanidol (procyanidins) specifically for wrinkle reduction. Therefore, while there is some scientific basis for its use, the evidence is moderate at best.

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