Evidence supporting the use of: Resveratrol conjugates (mixed)
For the health condition: Wrinkles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol conjugates (such as resveratrol glucuronides and sulfates) are metabolites of resveratrol, a polyphenol found in grapes, berries, and red wine. The primary scientific rationale for using resveratrol or its conjugates to treat or prevent wrinkles is based on their antioxidant and anti-inflammatory properties, which can theoretically protect skin cells from oxidative stress and inflammation—key contributors to skin aging and wrinkle formation. In vitro studies and some animal models have shown that resveratrol can stimulate the production of collagen and inhibit the activity of enzymes that degrade the skin’s extracellular matrix. Additionally, topical resveratrol formulations have demonstrated some protective effects against UV-induced skin damage in laboratory settings.

However, direct clinical evidence supporting the efficacy of resveratrol conjugates specifically (rather than resveratrol itself) for treating wrinkles in humans is limited. Most human studies involve topical application of resveratrol, often in combination with other ingredients, and report modest improvements in skin appearance and elasticity. Oral supplementation is less studied, and since resveratrol is rapidly metabolized into conjugates with uncertain activity, its bioavailability and effectiveness when taken orally remain questionable. As such, while mechanistic and preclinical evidence supports a potential anti-wrinkle effect, robust, large-scale clinical trials are lacking. Therefore, the scientific evidence for using resveratrol conjugates to treat wrinkles rates as limited (2/5).

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