Vitamin E, including its water-soluble form tocofersolan, has been used in dermatology and cosmetics with the aim of supporting skin health and mitigating wrinkles. The rationale is based on Vitamin E’s antioxidant properties, which help neutralize free radicals implicated in skin aging and the formation of wrinkles. There is scientific literature indicating that topical Vitamin E may help reduce oxidative stress in the skin, which is a contributor to photoaging and wrinkle formation. Some small clinical studies and in vitro research show that Vitamin E can improve skin moisture and barrier function, and might offer some photoprotection when combined with other antioxidants such as Vitamin C.

However, the direct evidence specifically supporting Vitamin E or tocofersolan as a primary treatment for wrinkles is limited. Most studies test combinations of antioxidants, making it difficult to isolate the effect of Vitamin E alone. There are few high-quality randomized controlled trials demonstrating significant clinical improvements in wrinkles with Vitamin E use. Also, the majority of research involves topical application, while tocofersolan is primarily used orally for Vitamin E supplementation in patients with malabsorption. As a result, while there is a plausible scientific rationale and some supportive data, the evidence base is weak and does not robustly justify its use solely for wrinkle reduction.