$79.00
Cost per day: $1.32
The Vitabase Advantage
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Availability: In stock as of 06/26/2025
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Technical information
Ingredient list
| Ingredient | Amount |
| SAMe (S-adenosylmethionine) (from S-adenosyl-L-methionine disulfate tosylate) | 200 mg |
Other ingredients: vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), calcium oxide, ascorbyl palmitate, calcium chloride
Recommended use
As a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.
Serving size: 1-2
Days Supply: 30 - 60
Cost Per Day: $1.32
Product Categories: Pure Encapsulations, Aging, Bones, Brain, Cellular, Cognition / Focus, Detox / Cleansing, General / Foundational Health, Joints, Memory, Mental Health / Nervous System, Mood, Skeletal
UPC: 766298015040
Product Information
Why take this product?
- Supports healthy methylation processes and glutathione production.
- Promotes brain function and supports a positive mood.
- Boosts joint comfort, flexibility, and overall joint integrity.
- Supports neurotransmitter production, cell membrane health, and cellular growth.
- Provides stable, bioavailable SAMe for optimal effectiveness.
- Crafted with premium vegan ingredients and supported by credible scientific research.
How it works
SAMe (S-adenosylmethionine) is a vital metabolite naturally present in every living cell, playing a crucial role in numerous biological processes. It is a primary methyl group donor, essential for over 100 different biochemical reactions that regulate genetic expression, cellular function, and the production of critical compounds such as neurotransmitters, hormones, nucleic acids, and proteins. Methylation, supported by SAMe, is essential for maintaining cellular health, promoting balanced hormone production, optimizing energy metabolism, and ensuring proper neurotransmitter activity.
One of the standout benefits of SAMe is its ability to support mood and cognitive health. Studies have shown that SAMe promotes the synthesis and function of key neurotransmitters like dopamine and serotonin, which are integral to emotional well-being. A meta-analysis of 25 clinical trials involving over 700 participants demonstrated SAMe’s statistically significant role in improving mood. By enhancing neurotransmitter pathways through its methylation properties, SAMe is a natural choice for individuals seeking cognitive clarity and emotional balance.
SAMe also plays a pivotal role in promoting joint comfort and flexibility. Clinical research, including multiple meta-analyses and randomized controlled trials, has found that SAMe significantly supports joint function by aiding proteoglycan synthesis and stabilizing these vital molecules within cartilage. This mechanism helps maintain joint structure and provides relief from discomfort, making SAMe an ideal supplement for those experiencing joint stiffness or seeking to preserve long-term mobility.
Additionally, SAMe supports overall cellular health by contributing to the production of glutathione, the body’s master antioxidant. Glutathione protects cells from oxidative stress, promoting a healthy inflammatory response and balancing cytokine activity. SAMe also stimulates polyamine synthesis, including spermidine and spermine, which are crucial for healthy cell growth and function. Whether for cognitive support, joint health, or enhanced cellular resilience, SAMe is a scientifically backed, multi-functional supplement designed to support optimal well-being at the cellular level.
