Designs for Health Inflammatone™ | Inflammation Support

Name: Inflammatone™
Brand: Designs For Health
SKU: DH-INF120
Price: 76.49 USD
Availability: InStock

Explore Designs for Health Inflammatone™: a blend of herbs, enzymes & nutrients that supports balanced inflammation, joint mobility & lymphatic drainage.

Overview

What Is Designs for Health Inflammatone™?

Designs for Health Inflammatone™ is a premium blend of herbs, nutrients, and proteolytic enzymes designed to support a balanced inflammatory response and promote overall wellness. By targeting the body's natural inflammatory pathways, Inflammatone™ aids in maintaining comfort and mobility, making it an essential choice for those seeking to optimize their health and vitality. Its carefully selected ingredients also help protect the body from oxidative stress, a key factor in aging and chronic conditions.

This advanced formula is particularly effective in promoting the natural clearance of proteins such as kinin and fibrin, which are often associated with inflammation and tissue repair. By assisting in the efficient breakdown and removal of these proteins, Inflammatone™ supports healthy lymphatic drainage, a critical component of immune function and detoxification.

Inflammatone™ stands out as an all-natural approach to inflammation management, addressing discomfort without relying on synthetic or harsh chemicals. The synergistic blend of botanical extracts and nutrients has been formulated based on the latest scientific research to ensure efficacy and safety.

Key Benefits

How Inflammatone™ Supports Your Body

Designs for Health Inflammatone™ brings together multiple mechanisms of action to deliver comprehensive support for inflammatory balance, joint health, and tissue recovery:

Supports a balanced inflammatory response — Ingredients such as boswellia, Turmeric, Ginger, and Quercetin target key inflammatory pathways including NF-κB, COX-2, and 5-lipoxygenase (5-LOX), helping to modulate the production of pro-inflammatory mediators.
Helps preserve joint health and mobility — Multiple clinical studies suggest that boswellia, Turmeric, and Ginger may support joint comfort, range of motion, and walking distance in those experiencing joint stiffness.
Enhances the body's antioxidant defenses — Rosemary extract, Quercetin, Rutin, and trans Resveratrol contribute potent antioxidant activity, helping to combat oxidative stress that can damage tissues over time.
Aids in natural recovery — Proteolytic enzymes including Trypsin, Chymotrypsin, and Serratiopeptidase support the natural clearance of fibrin and protein debris from injured tissues, promoting healthy tissue repair during postoperative and post-injury recovery.
Promotes healthy lymphatic drainage — The enzymatic and botanical components work together to facilitate the removal of excess fluid and protein accumulations that can impair lymphatic function.

This product is non-GMO, providing 120 capsules per bottle.

What's inside

Key Ingredients

Boswellia (as Boswellin® Extract) (Boswellia serrata)(resin) [standardized to contain 70% boswellic acids] — 200 mg

Boswellia serrata is an Ayurvedic botanical whose gum resin contains boswellic acids—particularly AKBA (3-O-acetyl-11-keto-β-boswellic acid)—that are potent, specific inhibitors of 5-lipoxygenase (5-LOX), blocking leukotriene B4 synthesis, and also suppress NF-κB signaling, two central drivers of chronic inflammation. Research suggests significant benefits for joint health: a meta-analysis of 7 randomized controlled trials (n=545) confirmed meaningful reductions in pain, stiffness, and improvements in joint function in osteoarthritis, with benefits shown to persist for up to 15 days after stopping supplementation. Multiple RCTs report improved joint flexion, range of motion, and walking distance, with one 2024 double-blind study showing measurable improvements within 5 days. Boswellia also actively protects cartilage matrix by inhibiting enzymes that degrade extracellular matrix proteins, including collagenase, elastase, and matrix metalloproteinases (MMP-3, MMP-13). Clinical trials show reduced synovial fluid MMP-3 and radiographic evidence of improved knee joint space. Studies further demonstrate significant reductions in inflammatory biomarkers such as CRP, ESR, IL-6, TNF-α, and PGE2, while its immunomodulatory properties include suppression of pro-inflammatory cytokines and enhancement of anti-inflammatory IL-10. AKBA also protects intestinal barrier integrity by preventing disassembly of tight junction proteins, relevant to its documented benefits in inflammatory bowel conditions.

Chymotrypsin

Chymotrypsin is a serine protease enzyme naturally produced by the pancreas. For supplemental use it is extracted from bovine or porcine pancreatic tissue. It degrades damaged cells, necrotic material, and inflammatory mediators such as bradykinin, helping to restrict edema and pain at sites of tissue injury. Multiple clinical trials demonstrate that Trypsin:Chymotrypsin combinations significantly reduce post-traumatic and post-surgical edema, erythema, and inflammatory biomarkers. Research suggests its anti-edematous effects operate in part via the lymphatic system, facilitating clearance of protein-rich edema fluid and fibrin deposits that impair lymphatic drainage. By binding to alpha-2-macroglobulin in the blood, Chymotrypsin retains biological activity while being transported to sites of inflammation. Animal studies have also shown dose-dependent immunomodulatory effects, including decreased pro-inflammatory IL-17 and increased anti-inflammatory IL-4 and FoxP3, indicating immune-regulatory potential.

Ginger Extract (Zingiber officinale)(root) [standardized to contain 5% gingerol] — 200 mg

Ginger (Zingiber officinale) is one of the most widely consumed dietary spices, rich in gingerols and shogaols that suppress prostaglandin and leukotriene biosynthesis through inhibition of both cyclooxygenase (COX-1 and COX-2) and 5-lipoxygenase (5-LOX), as well as NF-κB signaling. Multiple RCTs and meta-analyses confirm statistically significant reductions in circulating inflammatory markers (CRP, hs-CRP, TNF-α) in populations with chronic inflammatory conditions such as osteoarthritis and type 2 diabetes. A 2025 network meta-analysis of 39 RCTs found Ginger demonstrated benefits for knee OA outcomes, while a 2015 meta-analysis of five placebo-controlled trials showed modest but significant OA pain and disability reductions. Ginger compounds have also been shown to reduce exercise-induced muscle pain by approximately 25% in a widely cited RCT using 2 g/day. Traditionally, Ginger is used in Ayurveda as a universal medicine supporting circulatory systems including the lymphatic, digestive, and respiratory systems, and its diaphoretic and circulatory-stimulating properties are considered to indirectly support lymph flow by increasing fluid movement through surrounding tissues.

Quercetin — 75 mg

Quercetin is a plant flavonol and one of the most abundant dietary flavonoids, recognized for potent antioxidant and anti-inflammatory properties. It suppresses the NF-κB and MAPK signaling pathways, inhibits COX-2 and lipoxygenase activity, and reduces pro-inflammatory cytokines including IL-6, TNF-α, and IL-1β. A randomized, double-blind, placebo-controlled trial in 50 women with rheumatoid arthritis found that 500 mg/day for 8 weeks significantly reduced morning stiffness, pain scores, disease activity (DAS-28), and plasma TNF-α. A 2025 network meta-analysis of 18 RA RCTs ranked Quercetin as the most effective plant substance for reducing VAS pain scores. In a 2021 pilot RCT of 72 OA patients, 500 mg/day Quercetin significantly reduced serum IL-6, hsCRP, and WOMAC pain scores versus placebo. Quercetin is also classified as a venoactive compound in pharmacological reviews of lymphedema treatment, reducing vascular leakage and capillary filtration rates. It stabilizes mast cells—inhibiting histamine secretion more effectively than cromolyn in vitro—and has demonstrated anti-inflammatory effects on circulating CRP and IL-6 in participants with diagnosed diseases. A meta-analysis of 13 RCTs found Quercetin significantly decreased exercise-induced muscle soreness and creatine kinase levels.

Rosemary Extract (Rosmarinus officinalis)(leaf) [standardized to contain 7% carnosic acid] — 50 mg

Rosemary (Rosmarinus officinalis) contains phenolic diterpenes—primarily carnosic acid and carnosol—responsible for approximately 90% of its antioxidant properties. These compounds modulate inflammatory signaling pathways including NF-κB, MAPK, Nrf2, SIRT1, and NLRP3 inflammasomes, reducing the expression of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. A 2025 double-blind RCT demonstrated that 12 weeks of Rosemary leaf powder in 72 rheumatoid arthritis patients significantly reduced disease activity scores, joint counts, pain scores, CRP, and ESR, providing direct human evidence of systemic anti-inflammatory effects. Carnosic acid and carnosol are potent scavengers of peroxyl radicals and hydroxyl radicals, and are effective inhibitors of lipid peroxidation, contributing robust antioxidant defense.

Rutin — 75 mg

Rutin (Quercetin-3-O-rutinoside) is a flavonoid glycoside found abundantly in citrus fruits, buckwheat, and many other plants. It inhibits NF-κB and MAPK signaling, suppresses pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 from human macrophages, and strengthens capillary walls to reduce their permeability and fragility. Research suggests Rutin helps reduce edema and improve circulation. Clinical trials using oxerutin (a semisynthetic hydroxyethyl-Rutin derivative) in lymphedema patients have shown improvement in lymphedema volume and symptoms, and Rutin is listed in pharmacological reviews as a venoactive compound for lymphedema management. A PubMed-indexed clinical trial in 52 lymphedema patients using a Rutin-containing combination showed significant reductions in limb circumference after 6 months. Rutin also upregulates COL1A1 (type I collagen) and COL3A1 (type III collagen) genes while downregulating MMP1, supporting structural integrity of collagen-based connective tissues. Additionally, rutoside has been shown to inhibit TNF-α, IL-1, IL-6, and nitric oxide from human activated macrophages and to reduce arthritic signs in adjuvant-induced arthritis animal models.

Serratiopeptidase

Serratiopeptidase is a proteolytic zinc metalloprotease enzyme originally isolated from Serratia sp. in the silkworm intestine. It exerts anti-inflammatory, analgesic, anti-edemic, and fibrinolytic effects primarily through the proteolytic degradation of inflammatory mediators including bradykinin, histamine, and serotonin. It also binds cyclooxygenase, suppressing interleukin and prostaglandin release. A 2013 systematic review identified 14 RCTs covering inflammatory conditions, and the enzyme has been in clinical use in Japan and Europe for approximately 40 years. A 2021 RCT in patients undergoing impacted third molar surgery showed Serratiopeptidase significantly improved trismus and reduced facial swelling compared to placebo. A 2024 RCT on ankle sprains found it more effective than paracetamol in reducing joint edema. Serratiopeptidase supports lymphatic drainage by degrading fibrinous deposits and reducing interstitial protein accumulation that impedes lymphatic flow. Its fibrinolytic property—dissolving fibrin—has direct relevance to maintaining patent lymphatic channels and reducing tissue fluid accumulation.

Trans Resveratrol (root) — 5 mg

Trans Resveratrol is a polyphenolic stilbenoid found in grape skins, Japanese knotweed, and other plant sources. It activates SIRT1, suppresses NF-κB signaling, and modulates AMPK pathways. Clinical meta-analyses confirm significant reductions in key inflammatory biomarkers—particularly TNF-α and hs-CRP—following supplementation. The ARTHROL Phase 3 RCT (n=142, double-blind, 6 months) assessed oral Resveratrol for painful knee OA. Preclinical and in vitro data robustly show Resveratrol inhibits inflammatory cytokines in articular cartilage and synovial cells, and a 2025 network meta-analysis of 18 RA RCTs ranked Resveratrol as the most effective plant substance for reducing DAS28 disease activity scores. Resveratrol also acts as an antioxidant, scavenging hydroxyl radicals, nitric oxide, and superoxide anion.

Trypsin

Trypsin is a serine endopeptidase produced by the pancreas that catalyzes the hydrolysis of peptide bonds, playing a key role in protein digestion and tissue repair. Multiple randomized controlled trials and a systematic review support oral enzyme combinations containing Trypsin as comparable to diclofenac (an NSAID) for pain and function in knee osteoarthritis. A 2025 crossover RCT demonstrated reductions in systemic inflammation and cartilage turnover markers. The Trypsin:Chymotrypsin combination has been in clinical use since the 1960s for post-surgical and post-traumatic inflammation and has been shown to promote faster resolution of edema. Trypsin activates protease-activated receptor 2 (PAR2), a key modulator of inflammatory and immunological reactions, and a double-blind RCT demonstrated that Trypsin-containing systemic enzyme therapy significantly reduced delayed onset muscle soreness and fatigue in athletes following eccentric exercise.

Turmeric (Curcuma longa)(root) [standardized to contain 95% curcuminoids] — 200 mg

Turmeric rhizome contains curcuminoids—primarily curcumin—that inhibit NF-κB, COX-2, JAK/STAT, and MAPK inflammatory pathways, downregulating cytokines such as TNF-α, IL-6, and IL-1β. Multiple systematic reviews and meta-analyses support significant benefits for knee osteoarthritis pain and function, with some analyses showing efficacy comparable to NSAIDs. A 2022 meta-analysis of 29 RCTs involving 2,396 participants across five types of arthritis confirmed statistically significant improvements. A 2025 network meta-analysis ranked curcumin among supplements with significant functional benefits for knee OA, with bioavailability-enhanced preparations demonstrating a 30% reduction in WOMAC pain. A 2025 systematic review confirmed significant reductions in fasting blood sugar, HbA1c, triglycerides, LDL cholesterol, CRP, TNF-α, and IL-6 in metabolic syndrome populations. For inflammatory bowel disease, a 2025 meta-analysis of 13 placebo-controlled RCTs demonstrated curcumin's significant efficacy in achieving clinical remission and response in ulcerative colitis patients. Turmeric has been traditionally used in Ayurvedic medicine for over 6,000 years for inflammatory conditions, joint disorders, and digestive complaints.

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Inflammatone™

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Inflammatone™

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Ideal Users

Who Is Inflammatone™ For?

Designs for Health Inflammatone™ is formulated for individuals seeking natural support for inflammatory balance, joint comfort, and tissue recovery. It may be particularly well-suited for:

Active adults who want to support joint health, mobility, and recovery from everyday physical activity or exercise-induced muscle soreness.
Those experiencing occasional joint stiffness who are looking for botanical and enzymatic support to promote flexibility and comfort.
Individuals recovering from minor injuries or postoperative procedures who want to support the body's natural tissue repair and recovery processes.
Anyone seeking antioxidant protection against oxidative stress, a key factor in aging and chronic conditions.
People looking to support healthy lymphatic drainage and the efficient clearance of proteins associated with inflammation and tissue repair.

Usage

How to Take Inflammatone™

Take 2 capsules per day between meals or as directed by your health-care practitioner.

Each bottle of Inflammatone™ contains 120 capsules, providing a 60-day supply at the suggested serving size of 2 capsules.

About the author

Written by Greg Howlett

Greg Howlett

Founder

Greg has spent over a decade helping customers choose the right natural-health products. He personally vets every formula we carry and writes these guides to cut through the marketing noise with practical, experience-based advice.

FAQ

Frequently asked questions

What makes Designs for Health Inflammatone™ different from a standard anti-inflammatory supplement?

Inflammatone™ combines a synergistic blend of herbs, nutrients, and proteolytic enzymes that work through multiple complementary mechanisms. While botanical extracts like boswellia, Turmeric, and Ginger target key inflammatory pathways such as NF-κB and 5-LOX, the proteolytic enzymes (Trypsin, Chymotrypsin, Serratiopeptidase) promote the natural clearance of proteins like kinin and fibrin, supporting healthy lymphatic drainage and tissue repair. This multi-pathway approach distinguishes it from single-ingredient formulas.

Is Inflammatone™ non-GMO?

Yes, Inflammatone™ is a non-GMO product.

When should I take Inflammatone™ — with or without food?

The directions specify taking 2 capsules per day between meals. Taking proteolytic enzyme-containing supplements between meals helps ensure that the enzymes are available for systemic activity rather than being used primarily for digestive purposes.

How does Inflammatone™ support joint health and mobility?

Several ingredients in Inflammatone™ have been studied for their effects on joint comfort and function. Research suggests boswellia may improve joint flexion, range of motion, and walking distance, with a meta-analysis of 7 RCTs confirming significant reductions in pain and stiffness. Turmeric and Ginger have also demonstrated benefits for joint pain and physical function in multiple clinical trials. The proteolytic enzymes further support recovery by aiding in the breakdown of fibrin and inflammatory debris in tissues.

How does Inflammatone™ support lymphatic drainage?

Inflammatone™ supports lymphatic drainage through several mechanisms. Proteolytic enzymes like Serratiopeptidase and Chymotrypsin facilitate clearance of protein-rich edema fluid and fibrinous deposits that can impair lymphatic flow. Quercetin and Rutin are classified as venoactive compounds that reduce vascular leakage and capillary filtration rates. Ginger is traditionally used in Ayurveda as a circulatory stimulant that indirectly supports lymph flow by increasing fluid movement through surrounding tissues.

How long does a bottle of Inflammatone™ last?

Each bottle contains 120 capsules. At the suggested serving size of 2 capsules per day, one bottle provides a 60-day supply.

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